Margatoxin

• Description:

  Margatoxin Catalog number: MDP0661 CAS Number: 212609-11-5 Sequence: Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Leu-Pro-Pro-Cys-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro-His (Reported disulfide bonds between Cys7-Cys29, Cys13-Cys34, and Cys17-Cys36) Amount: 100 ug Molecular Weight: 4178.8 g/mol Supplied as: Powder Applications: molecular tool for various biochemical applications Storage: -20 °C WARNING: For in vitro Research Use Only. NOT for use on humans or animals. Grade: Biotechnology grade. All products are highly pure. References: 1: Wu BM, Liu JD, Li YH, Li J. Margatoxin mitigates CCl4‑induced hepatic fibrosis in mice via macrophage polarization, cytokine secretion and STAT signaling Int J Mol Med. 2020 Jan;45(1):103-114. 2: Denisova KR, Orlov NA, Yakimov SA, Kryukova EA, Dolgikh DA, Kirpichnikov MP, Feofanov AV, Nekrasova OV. GFP-Margatoxin, a Genetically Encoded Fluorescent Ligand to Probe Affinity of Kv1.3 Channel Blockers Int J Mol Sci. 2022 Feb 2;23(3):1724. 3: Saria A, Seidl CV, Fischer HS, Koch RO, Telser S, Wanner SG, Humpel C, Garcia ML, Knaus HG. Margatoxin increases dopamine release in rat striatum via voltage-gated K+ channels Eur J Pharmacol. 1998 Feb 19;343(2-3):193-200. 4: Bartok A, Toth A, Somodi S, Szanto TG, Hajdu P, Panyi G, Varga Z. Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels Toxicon. 2014 Sep;87:6-16. 5: Schwartz AB, Kapur A, Wang W, Huang Z, Fardone E, Palui G, Mattoussi H, Fadool DA. Margatoxin-bound quantum dots as a novel inhibitor of the voltage-gated ion channel Kv1.3 J Neurochem. 2017 Feb;140(3):404-420. 6: Naseem MU, Tajti G, Gaspar A, Szanto TG, Borrego J, Panyi G. Optimization of Pichia pastoris Expression System for High-Level Production of Margatoxin Front Pharmacol. 2021 Sep 29;12:733610. 7: Knaus HG, Koch RO, Eberhart A, Kaczorowski GJ, Garcia ML, Slaughter RS. [125I]margatoxin, an extraordinarily high affinity ligand for voltage-gated potassium channels in mammalian brain Biochemistry. 1995 Oct 17;34(41):13627-34. 8: Saria A, Fischer HS, Humpel C, Pfattner A, Schatz DS, Schuligoi R. Margatoxin and iberiotoxin, two selective potassium channel inhibitors, induce c-fos like protein and mRNA in rat organotypic dorsal striatal slices Amino Acids. 2000;19(1):23-31. 9: Erdogan A, Schaefer CA, Schaefer M, Luedders DW, Stockhausen F, Abdallah Y, Schaefer C, Most AK, Tillmanns H, Piper HM, Kuhlmann CR. Margatoxin inhibits VEGF-induced hyperpolarization, proliferation and nitric oxide production of human endothelial cells J Vasc Res. 2005 Sep-Oct;42(5):368-76. 10: Helms LM, Felix JP, Bugianesi RM, Garcia ML, Stevens S, Leonard RJ, Knaus HG, Koch R, Wanner SG, Kaczorowski GJ, Slaughter RS. Margatoxin binds to a homomultimer of K(V)1.3 channels in Jurkat cells. Comparison with K(V)1.3 expressed in CHO cells Biochemistry. 1997 Mar 25;36(12):3737-44.
  Products Related to Margatoxin can be found at Peptides

• Short Description:

  Catalog Number: MDP0661 (100 ug)

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height:

  0.5