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Margatoxin

CAT: 0466-08MAG001-00500Size: 0.5 mgDry Ice: NoHazardous: No
CAT#:0466-08MAG001-00500Size:0.5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Margatoxin (MgTx) is a component of the venom of Scorpio Centruroides margaritatus. Margatoxin preferentially inhibits voltage-dependent potassium channels Kv1.3 with an IC50 value around 50 pM (20 fold more potent than Charybdotoxin) and irreversibly inhibits the proliferation response of human T-cells at 20 µM concentration. Margatoxin is known to be less potent on Kv1.3 expressed in Xenopus Oocytes (IC50 around 1 nM) . Margatoxin was also described to be a potent inhibitor of human vascular smooth muscle cell migration with an IC50 of 85 pM.
CAS Number
145808-47-5
Specifications
Kv1.3 selective blocker
Target
K channels
Sequence
TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH
Peptide Number
08MAG001
Disulfide Bonds
Cys7-Cys29; Cys13-Cys34; Cys17-Cys36
N Terminal Sequence
H
C Terminal Sequence
OH

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