1,4-DPCA

• Description :

  1,4-DPCA, a potent prolyl-4-hydroxylase inhibitor, is a collagen hydroxylation inhibitor in human foreskin fibroblasts with an IC50 of 2.4 µM. 1,4-DPCA inhibits prolyl-4-hydroxylases α isoforms stabilizes HIF-1α protein. 1,4-DPCA also inhibits factor inhibiting HIF (FIH) with an IC50 of 60 μM[1][2].

• UNSPSC :

  12352005

• Target :

  HIF/HIF Prolyl-Hydroxylase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/1-4-dpca.html

• Concentration :

  10mM

• Purity :

  98.36

• Solubility :

  DMSO : 12.5 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=CN=C2C3=NC=CC=C3C=CC2C1=O)O

• Molecular Formula :

  C13H8N2O3

• Molecular Weight :

  240.21

• References & Citations :

  [1]Yong Zhang, et al. Drug-induced regeneration in adult mice. Sci Transl Med. 2015 Jun 3;7 (290) :290ra92.|[2]Ryan J Love, et al. Transient inhibition of connective tissue infiltration and collagen deposition into porous poly (lactic-co-glycolic acid) discs. J Biomed Mater Res A. 2013 Dec;101 (12) :3599-606.|[3]Gaofeng Xiong, et al. Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition. BMC Cancer. 2014 Jan 2;14:1.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [331830-20-7]