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I-TAC rabbit pAb

CAT: 0855-ES20290-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES20290-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Disease:Expressed in a variety of skin disorders, including allergic contact dermatitis, lichen planus and mycosis fungoides., function:Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses., induction:By interferon gamma and interferon beta. Induction by IFN-gamma is enhanced by TNF-alpha in monocytes, dermal fibroblasts and endothelial cells, and by IL-1 in astrocytes., mass spectrometry: PubMed:10233762, online information:CXCL11 entry, similarity:Belongs to the intercrine alpha (chemokine CxC) family., tissue specificity:High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.
Description
Disease: Expressed in a variety of skin disorders, including allergic contact dermatitis, lichen planus and mycosis fungoides. function: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses. induction: By interferon gamma and interferon beta. Induction by IFN-gamma is enhanced by TNF-alpha in monocytes, dermal fibroblasts and endothelial cells, and by IL-1 in astrocytes. mass spectrometry: PubMed: 10233762, online information: CXCL11 entry, similarity: Belongs to the intercrine alpha (chemokine CxC) family. tissue specificity: High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.
UniProt
O14625
Swiss Prot
O14625
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human I-TAC AA range: 45-94
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Secreted.
Other Product Names
C-X-C motif chemokine 11 (Beta-R1; H174; Interferon gamma-inducible protein 9; IP-9; Interferon-inducible T-cell alpha chemoattractant; I-TAC; Small-inducible cytokine B11)
Gene ID (Human)
6373

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