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HXK I rabbit pAb

CAT: 0855-ES2587-01Size: 50 µLDry Ice: NoHazardous: No
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Background
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms, some of which are tissue-specific. [provided by RefSeq, Apr 2016]
Description
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms, some of which are tissue-specific. [provided by RefSeq, Apr 2016],
UniProt
P19367
Swiss Prot
P19367
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human HXK1. AA range:31-80
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
109kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
109kD
Fragment
IgG
Subcellular Location
Mitochondrion outer membrane ; Peripheral membrane protein . Cytoplasm, cytosol . The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (Probable) . Dissociates from the mitochondrial outer membrane following inhibition by N-acetyl-D-glucosamine, leading to relocation to the cytosol (PubMed:27374331) . .
Other Product Names
HK1; Hexokinase-1; Brain form hexokinase; Hexokinase type I; HK I
Gene ID (Human)
3098

UniProtKB · P19367

Hexokinase-1

HXK1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P19367
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HK1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.1.1
Processing
—
Secondary accessions
E9PCK0, O43443, O43444, O75574, Q5VTC3, Q96HC8, Q9NNZ4, Q9NNZ5
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Molecular function

Allosteric enzymeKinaseTransferase

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Disease

Charcot-Marie-Tooth diseaseDisease variantHereditary hemolytic anemiaIntellectual disabilityNeurodegenerationNeuropathyRetinitis pigmentosa

Cellular component

CytoplasmMembraneMitochondrionMitochondrion outer membrane

Biological process

GlycolysisImmunityInflammatory responseInnate immunity

Domain

Repeat

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