L-Thyroxine
CAT:
804-HY-18341-01
Size:
500 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
L-Thyroxine
- CAS Number: 51-48-9
- UNSPSC Description: L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[1].
- Target Antigen: Endogenous Metabolite; Thyroid Hormone Receptor
- Type: Natural Products
- Related Pathways: Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
- Field of Research: Endocrinology; Cancer
- Assay Protocol: https://www.medchemexpress.com/l-thyroxine.html
- Purity: 99.49
- Solubility: 1M NaOH : 5 mg/mL (ultrasonic;warming;adjust pH to 11 with NaOH;heat to 60°C)|DMSO : 233.33 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: N[C@@H](CC1=CC(I)=C(C(I)=C1)OC2=CC(I)=C(O)C(I)=C2)C(O)=O
- Molecular Weight: 776.87
- References & Citations: [1]Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65(3):317-323.|[2]Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2(4):144-149.Cell Rep Med. 2023 May 24;101061.|Dis Model Mech. 2024 Aug 14:dmm.050748.|EMBO J. 2024 Jun 5.|Mol Brain. 2021 Jan 27;14(1):25.|Nat Immunol. 2024 Mar 18.|Sci Rep. 2022 Jul 4;12(1):11259.|Stem Cell Rev Rep. 2021 Jun;17(3):999-1013.|J Drug Deliv Sci Technol. 2023 Sep 28, 105008.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: Launched