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Guanylin (mouse, rat)

CAT: 0804-HY-P5077Size: 1 EachDry Ice: NoHazardous: No
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Description
Guanylin (mouse, rat), a petide, is composed of 15 amino acids. Guanylin (mouse, rat) is an activator of intestinal guanylate cyclase. Guanylin (mouse, rat) can be used for the research of diarrhea[1].
CAS Number
145257-03-0
UNSPSC
12352209
Target
Guanylate Cyclase
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/guanylin-mouse-rat.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](NC([C@@]1([H])NC([C@](NC([C@@H](NC([C@H](CSSC[C@](C(N[C@@](C(NCC(N[C@@H](CSSC1)C(O)=O)=O)=O)([H])[C@H](O)C)=O)([H])NC([C@@H](NC([C@@H](NC2=O)C)=O)C)=O)NC([C@H]([C@H](O)C)NC([C@H](CC(N)=O)NC([C@@H]3CCCN3)=O)=O)=O)=O)CCC(O)=O)=O)([H])[C@@H](C)CC)=O)=O)C)N[C@H]2CC4=CC=C(C=C4)O
Molecular Formula
C60H90N16O22S4
Molecular Weight
1515.71
References & Citations
[1]Currie MG, et al. Guanylin: an endogenous activator of intestinal guanylate cyclase. Proc Natl Acad Sci U S A. 1992 Feb 1;89 (3) :947-51.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

Guanylin (rat, mouse)
CAS Number145257-03-0
PubChem CID90470068
IUPAC Name(1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-25-[[(2S,3R)-2-[[(2S)-4-amino-4-oxo-2-[[(2S)-pyrrolidine-2-carbonyl]amino]butanoyl]amino]-3-hydroxybutanoyl]amino]-19-[(2S)-butan-2-yl]-22-(2-carboxyethyl)-32-[(1R)-1-hydroxyethyl]-10-[(4-hydroxyphenyl)methyl]-4,7,13-trimethyl-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecazabicyclo[14.13.13]dotetracontane-38-carboxylic acid
Molecular FormulaC60H90N16O22S4
Molecular Weight1515.7
XLogP-6.5
Topological Polar Surface Area699
Hydrogen Bond Donor Count21
Hydrogen Bond Acceptor Count27
Rotatable Bond Count18
Heavy Atom Count102
Formal Charge0
Complexity3050
SMILES
CC[C@H](C)[C@H]1C(=O)N[C@H]2CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N1)CCC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@@H]3CCCN3)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)C)CC4=CC=C(C=C4)O)C)C)[C@@H](C)O)C(=O)O
InChI
InChI=1S/C60H90N16O22S4/c1-8-25(2)44-58(95)72-37-21-101-102-24-40(60(97)98)67-42(81)20-63-57(94)45(29(6)77)75-56(93)39(71-49(86)27(4)64-47(84)26(3)65-52(89)35(18-31-11-13-32(79)14-12-31)69-48(85)28(5)66-54(37)91)23-100-99-22-38(55(92)68-34(51(88)74-44)15-16-43(82)83)73-59(96)46(30(7)78)76-53(90)36(19-41(61)80)70-50(87)33-10-9-17-62-33/h11-14,25-30,33-40,44-46,62,77-79H,8-10,15-24H2,1-7H3,(H2,61,80)(H,63,94)(H,64,84)(H,65,89)(H,66,91)(H,67,81)(H,68,92)(H,69,85)(H,70,87)(H,71,86)(H,72,95)(H,73,96)(H,74,88)(H,75,93)(H,76,90)(H,82,83)(H,97,98)/t25-,26-,27-,28-,29+,30+,33-,34-,35-,36-,37-,38-,39-,40-,44-,45-,46-/m0/s1
InChIKey
VGFLUTOEMABSGC-RAJPIYRYSA-N
Chemical Structure
2D Structure
2D structure of Guanylin (rat, mouse)
CAS: 145257-03-0
CID: 90470068
Formula: C60H90N16O22S4
MW: 1515.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1515.7
XLogP3-6.5
Hydrogen Bond Donor Count21
Hydrogen Bond Acceptor Count27
Rotatable Bond Count18
Exact Mass1514.52984326
Monoisotopic Mass1514.52984326
Topological Polar Surface Area699 Ų
Heavy Atom Count102
Formal Charge0
Complexity3050
Isotope Atom Count0
Defined Atom Stereocenter Count17
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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