ZD-6888 (hydrochloride)

• UNSPSC Description:

  ZD-6888 hydrochloride (ICI-D 6888 hydrochloride) is an antagonist for angiotensin II, which competitively inhibits the angiotensin II-mediated release of renin, affects the renal structure and function[1].

• Target Antigen:

  Angiotensin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/zd-6888-hydrochloride.html

• Smiles:

  CCC1=NC2=C(CCCC2)C(OCC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3)=C1.Cl

• Molecular Weight:

  447.96

• References & Citations:

  [1]Jackson DG, et al., Histopathological and ultrastructural changes in the juxtaglomerular apparatus of the rat following administration of ZENECA ZD6888 (2-ethyl-5,6,7,8-tetrahydro-4-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)- methoxy]quinoline), an angiotensin II antagonist. Toxicol Pathol. 1995 Jan-Feb;23(1):7-15.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 1

• CAS Number:

  138620-17-4