ZD-1611

• Description :

  ZD-1611 is a potent, orally active, selective ETA receptor antagonist, used for the research of ischemic stroke.

• UNSPSC :

  12352005

• Target :

  Endothelin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Cardiovascular Disease; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/ZD-1611.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(O)C(C)(C)CC1=CC=C(C2=NC=CC=C2S(=O)(NC3=NC=C(C)N=C3OC)=O)C=C1

• Molecular Formula :

  C22H24N4O5S

• Molecular Weight :

  456.51

• References & Citations :

  [1]Wilson C, et al. Pharmacological profile of ZD1611, a novel, orally active endothelin ETA receptor antagonist. J Pharmacol Exp Ther. 1999 Sep;290 (3) :1085-91.|[2]Stenman E, et al. Cooperative effect of angiotensin AT (1) and endothelin ET (A) receptor antagonism limits the brain damage after ischemic stroke in rat. Eur J Pharmacol. 2007 Sep 10;570 (1-3) :142-8. Epub 2007 Jun 9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  ETA

• CAS Number :

  [186497-38-1]