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ZD-1611

CAT: 0804-HY-19274Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-19274Size:1 Each
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Description
ZD-1611 is a potent, orally active, selective ETA receptor antagonist, used for the research of ischemic stroke.
CAS Number
186497-38-1
UNSPSC
12352005
Target
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/ZD-1611.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C(C)(C)CC1=CC=C(C2=NC=CC=C2S(=O)(NC3=NC=C(C)N=C3OC)=O)C=C1
Molecular Formula
C22H24N4O5S
Molecular Weight
456.51
References & Citations
[1]Wilson C, et al. Pharmacological profile of ZD1611, a novel, orally active endothelin ETA receptor antagonist. J Pharmacol Exp Ther. 1999 Sep;290 (3) :1085-91.|[2]Stenman E, et al. Cooperative effect of angiotensin AT (1) and endothelin ET (A) receptor antagonism limits the brain damage after ischemic stroke in rat. Eur J Pharmacol. 2007 Sep 10;570 (1-3) :142-8. Epub 2007 Jun 9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
ETA

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