9-Phenanthrol

• Description :

  9-Phenanthrol (9-Hydroxyphenanthrene) is a selective TRPM4 inhibitor with an IC50 of 17 μM. 9-Phenanthrol has no inhibitory activity on TRPM5, TRPC6, and CFTR. 9-Phenanthrol can be used for the research of ischemia-reperfusion injury[1][2].

• Product Name Alternative :

  9-Hydroxyphenanthrene; NSC 50554

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  TRP Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/9-phenanthrol.html

• Purity :

  99.61

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  OC1=CC2=CC=CC=C2C3=CC=CC=C13

• Molecular Formula :

  C14H10O

• Molecular Weight :

  194.23

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Wang J, et, al. 9-Phenanthrol, a TRPM4 inhibitor, protects isolated rat hearts from ischemia-reperfusion injury. PLoS One. 2013 Jul 25;8 (7) :e70587. |[2]Guinamard R, et al. The TRPM4 channel inhibitor 9-phenanthrol. Br J Pharmacol. 2014 Apr;171 (7) :1600-13.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  TRPM4

• CAS Number :

  [484-17-3]