9-Phenanthrol

• Description:

  9-Phenanthrol (9-Hydroxyphenanthrene) is a selective TRPM4 inhibitor with an IC50 of 17 μM. 9-Phenanthrol has no inhibitory activity on TRPM5, TRPC6, and CFTR. 9-Phenanthrol can be used for the research of ischemia-reperfusion injury[1][2].

• Product Name Alternative:

  9-Hydroxyphenanthrene; NSC 50554

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  TRP Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/9-phenanthrol.html

• Purity:

  99.61

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  OC1=CC2=CC=CC=C2C3=CC=CC=C13

• Molecular Formula:

  C14H10O

• Molecular Weight:

  194.23

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Wang J, et, al. 9-Phenanthrol, a TRPM4 inhibitor, protects isolated rat hearts from ischemia-reperfusion injury. PLoS One. 2013 Jul 25;8 (7) :e70587. |[2]Guinamard R, et al. The TRPM4 channel inhibitor 9-phenanthrol. Br J Pharmacol. 2014 Apr;171 (7) :1600-13.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  TRPM4

• CAS Number:

  [484-17-3]