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Mifepristone-d6

CAT: 0804-HY-13683S2-01Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-13683S2-01Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mifepristone-d6 is deuterated labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1].
CAS Number
1228097-18-4
Product Name Alternative
RU486-d6; RU 38486-d6
UNSPSC
12352005
Target
Autophagy; Endogenous Metabolite; Glucocorticoid Receptor; Isotope-Labeled Compounds; NO Synthase; Progesterone Receptor
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Endocrinology
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@@](C#CC)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CCC4=C3[C@@H](C5=CC=C(N(C([2H])([2H])[2H])C([2H])([2H])[2H])C=C5)C2)=O
Molecular Formula
C29H29D6NO2
Molecular Weight
435.63
References & Citations
[1]Jurado R, et al. NSC 119875 cytotoxicity is increased by mifepristone in cervical carcinoma: an in vitro and in vivo study. Oncol Rep. 2009 Nov;22 (5) :1237-45.|[2]Sharrett-Field L, et al. Mifepristone Pretreatment Reduces Ethanol Withdrawal Severity In Vivo. Alcohol Clin Exp Res. 2013 Aug;37 (8) :1417-23.|[3]Jiang W, et al. New progesterone receptor antagonists: phosphorus-containing 11beta-aryl-substituted steroids. Bioorg Med Chem. 2006 Oct 1;14 (19) :6726-32.|[4]Yuehua You, et al. Progesterone Promotes Endothelial Nitric Oxide Synthase Expression Through Enhancing Nuclear Progesterone receptor-SP1 Formation. Am J Physiol Heart Circ Physiol. 2020 Jul 3.|[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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