22-Hydroxy mifepristone

• UNSPSC Description:

  22-Hydroxy Mifepristone (RU 42698) is an orally active hydroxylated alcoholic metabolite with antiprogestational and antiglucocorticoidal activities, which contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. The relative binding affinity of 22-Hydroxy Mifepristone to the human glucocorticoid receptor is 48%[1][2].

• Target Antigen:

  Endogenous Metabolite; Glucocorticoid Receptor

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/22-hydroxy-mifepristone.html

• Smiles:

  O=C1C=C2C(CC1)=C3[C@@H](C4=CC=C(N(C)C)C=C4)C[C@@]5(C)[C@@]([C@]3(C)CC2)(C)CC[C@]5(C#CCO)O

• Molecular Weight:

  473.65

• References & Citations:

  [1]Lähteenmäki P, et al. Pharmacokinetics and metabolism of RU 486. J Steroid Biochem. 1987;27(4-6):859-63.|[2]Heikinheimo O, et al. Plasma concentrations and receptor binding of RU 486 and its metabolites in humans. J Steroid Biochem. 1987 Feb;26(2):279-84.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  105012-15-5