22-Hydroxy mifepristone

22-Hydroxy mifepristone

• CAS Number: 105012-15-5
• UNSPSC Description: 22-Hydroxy Mifepristone (RU 42698) is an orally active hydroxylated alcoholic metabolite with antiprogestational and antiglucocorticoidal activities, which contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. The relative binding affinity of 22-Hydroxy Mifepristone to the human glucocorticoid receptor is 48%[1][2].
• Target Antigen: Endogenous Metabolite; Glucocorticoid Receptor
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/22-hydroxy-mifepristone.html
• Smiles: O=C1C=C2C(CC1)=C3[C@@H](C4=CC=C(N(C)C)C=C4)C[C@@]5(C)[C@@]([C@]3(C)CC2)(C)CC[C@]5(C#CCO)O
• Molecular Weight: 473.65
• References & Citations: [1]Lähteenmäki P, et al. Pharmacokinetics and metabolism of RU 486. J Steroid Biochem. 1987;27(4-6):859-63.|[2]Heikinheimo O, et al. Plasma concentrations and receptor binding of RU 486 and its metabolites in humans. J Steroid Biochem. 1987 Feb;26(2):279-84.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported