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Tolbutamide-13C

CAT: 0804-HY-B0401S1-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0401S1-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tolbutamide-13C is the 13C-labeled Tolbutamide. Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic agent.
UNSPSC
12352005
Target
Autophagy; Isotope-Labeled Compounds; Potassium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Membrane Transporter/Ion Channel; Others
Field of Research
Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/tolbutamide-13c.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(C)C=C1)(NC(N[13C]CCC)=O)=O
Molecular Formula
C11 13CH16N2O3S
Molecular Weight
269.32
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Wray, H.L. and A.W. Harris, Adenosine 3', 5'-monophosphate-dependent protein kinase in adipose tissue: inhibition by tolbutamide. Biochem Biophys Res Commun, 1973. 53 (1) : p. 291-4.|[3]Sanchez-Alvarez, R., et al., Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up-regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation. Glia, 2006. 54 (2) : p. 125-34.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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