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Tolbutamide (sodium)

CAT: 0804-HY-B0401ASize: 1 EachDry Ice: NoHazardous: No
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Description
Tolbutamide sodium is a potent and orally active antidiabetic agent. Tolbutamide sodium induces apoptosis in a Ca2+ dependent manner in pancreatic β-cells. Tolbutamide sodium has the potential for the research of non-insulin-dependent diabetes mellitus[1][2].
CAS Number
473-41-6
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/tolbutamide-sodium.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(C)C=C1)(NC(NCCCC)=O)=O.[Na]
Molecular Formula
C12H18N2NaO3S
Molecular Weight
293.34
References & Citations
[1]Trube G, et al. Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells. Pflugers Arch. 1986 Nov;407 (5) :493-9.|[2]Efanova IB, et al. Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration. J Biol Chem. 1998 Dec 11;273 (50) :33501-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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