Products for Research Use Only
RegisterLogin

BTdCPU

CAT: 0804-HY-118266-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-118266-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
BTdCPU is a potent heme regulated inhibitor kinase (HRI) activator that promotes eIF2α phosphorylation and induces apoptosis in Dexamethasone (Dex) -resistant cancer cells. BTdCPU can be used in the study of cancers such as multiple myeloma and Dex-resistant multiple myeloma[1][2].
CAS Number
1257423-87-2
Product Name Alternative
BR-941
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Phosphatase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/btdcpu.html
Purity
99.03
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C2N=NSC2=C1)NC3=CC=C(C(Cl)=C3)Cl
Molecular Formula
C13H8Cl2N4OS
Molecular Weight
339.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Burwick N, et al. The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma. Leuk Res. 2017 Apr;55:23-32. |[2]Chen T, et al. Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target. Nat Chem Biol. 2011 Jul 17;7 (9) :610-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

1-(Benzo[d][1,2,3]thiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea
CAS Number1257423-87-2
PubChem CID49787174
IUPAC Name1-(1,2,3-benzothiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea
Molecular FormulaC13H8Cl2N4OS
Molecular Weight339.2
XLogP3.7
Topological Polar Surface Area95.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity389
SMILES
C1=CC2=C(C=C1NC(=O)NC3=CC(=C(C=C3)Cl)Cl)SN=N2
InChI
InChI=1S/C13H8Cl2N4OS/c14-9-3-1-7(5-10(9)15)16-13(20)17-8-2-4-11-12(6-8)21-19-18-11/h1-6H,(H2,16,17,20)
InChIKey
NUUSUAWULNXMGF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-(Benzo[d][1,2,3]thiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea
CAS: 1257423-87-2
CID: 49787174
Formula: C13H8Cl2N4OS
MW: 339.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight339.2
XLogP33.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass337.9795875
Monoisotopic Mass337.9795875
Topological Polar Surface Area95.2 Ų
Heavy Atom Count21
Formal Charge0
Complexity389
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
M20636-01BTdCPU
217337-01EIF2-GTP-tRNAiMet Ternary Complex Inhibitor, BTdCPU (N, N'-diarylurea; translation Initiation Tenrary Complex Inhibitor, 1- (benzo[d][1,2,3]thiadiazol-6-yl) -3- (3,4-dichlorophenyl) urea, BTdCPU, Heme-regulated Inhibitor Kinase Activator, BTdCPU)

Popular Products