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LT175

CAT: 0804-HY-121900-04Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121900-04Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LT175, a dual PPARα/γ ligand, is an orally active partial agonist against PPARγ (hPPARα:EC50=0.22 μm; mPPARα:EC50=0.26 μm; hPPARγ:EC50=0.48 μm) . LT175 interacts with PPARγ and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1) . LT175 interacts with PPARγ in a hydrophobic region called "diphenyl pocket" . LT175 has potent insulin-sensitizing effects and reduced adipogenic properties[1].
CAS Number
862901-87-9
UNSPSC
12352005
Hazard Statement
H301-H312-H330-H410
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/lt175.html
Purity
99.79
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H](OC1=CC=C(C2=CC=CC=C2)C=C1)CC3=CC=CC=C3)O
Molecular Formula
C21H18O3
Molecular Weight
318.37
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Federica Gilardi, et al. LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties. J Biol Chem. 2014 Mar 7;289 (10) :6908-6920.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARα; PPARγ

Chemical Information

LT175
CAS Number862901-87-9
PubChem CID11483970
IUPAC Name(2S)-3-phenyl-2-(4-phenylphenoxy)propanoic acid
Molecular FormulaC21H18O3
Molecular Weight318.4
XLogP5.1
Topological Polar Surface Area46.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Heavy Atom Count24
Formal Charge0
Complexity375
SMILES
C1=CC=C(C=C1)C[C@@H](C(=O)O)OC2=CC=C(C=C2)C3=CC=CC=C3
InChI
InChI=1S/C21H18O3/c22-21(23)20(15-16-7-3-1-4-8-16)24-19-13-11-18(12-14-19)17-9-5-2-6-10-17/h1-14,20H,15H2,(H,22,23)/t20-/m0/s1
InChIKey
TZTPJJNNACUQQR-FQEVSTJZSA-N
Chemical Structure
2D Structure
2D structure of LT175
CAS: 862901-87-9
CID: 11483970
Formula: C21H18O3
MW: 318.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight318.4
XLogP35.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Exact Mass318.125594432
Monoisotopic Mass318.125594432
Topological Polar Surface Area46.5 Ų
Heavy Atom Count24
Formal Charge0
Complexity375
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5802264LT175

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