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LT175

CAT: 0804-HY-121900-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121900-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LT175, a dual PPARα/γ ligand, is an orally active partial agonist against PPARγ (hPPARα:EC50=0.22 μm; mPPARα:EC50=0.26 μm; hPPARγ:EC50=0.48 μm) . LT175 interacts with PPARγ and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1) . LT175 interacts with PPARγ in a hydrophobic region called "diphenyl pocket" . LT175 has potent insulin-sensitizing effects and reduced adipogenic properties[1].
CAS Number
862901-87-9
UNSPSC
12352005
Hazard Statement
H301-H312-H330-H410
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/lt175.html
Purity
99.79
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H](OC1=CC=C(C2=CC=CC=C2)C=C1)CC3=CC=CC=C3)O
Molecular Formula
C21H18O3
Molecular Weight
318.37
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Federica Gilardi, et al. LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties. J Biol Chem. 2014 Mar 7;289 (10) :6908-6920.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARα; PPARγ

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CatalogName
MBS5802264LT175

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