Products for Research Use Only
RegisterLogin

JNJ-61432059

CAT: 0804-HY-111751-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-111751-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models[1].
CAS Number
2035814-50-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/JNJ-61432059.html
Purity
99.18
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1CCN(C2=NC=CC3=C(C4=CC=C(NC(C5)=O)C5=C4)C(C6=CC=C(F)C=C6)=NN32)CC1
Molecular Formula
C25H22FN5O2
Molecular Weight
443.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Savall BM, et al. Discovery of Imidazo[1,2-a]pyrazines and Pyrazolo[1,5-c]pyrimidines as TARP γ-8 Selective AMPAR Negative Modulators. ACS Med Chem Lett. 2018 Dec 26;10 (3) :267-272.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor

Related Products

CatalogName
HY-172194JNJ-3738
HY-P991172JNJ-70218902
HY-113751-01JNJ-39393406
HY-132895JNJ-67569762
HY-118424-01JNJ-55511118
HY-110132-01JNJ-27141491
HY-19917-01JNJ-39220675
HY-123531JNJ 10329670
HY-148240-01JNJ-65355394
HY-111066-01JNJ-37822681

Alternative Products

CatalogName
BA6753-5.1JNJ-61432059
A20209-50JNJ-61432059 50mg
A20209-1JNJ-61432059 1mg
A20209-100JNJ-61432059 100mg
A20209-10JNJ-61432059 10mg
A20209-25JNJ-61432059 25mg
A20209-5JNJ-61432059 5mg
A20209-10mM-DJNJ-61432059 10mM * 1mL in DMSO
MBS131356JNJ-63533054 (JNJ63533054; JNJ 63533054)
BA6861-10JNJ-42253432

Popular Products