NBD-2

• Description :

  NBD-2 is an inhibitor of the NEMO-IKKα/β interaction in the NF-κB signaling pathway. NBD-2 specifically inhibits the typical NF-κB signaling pathway in vitro and in vivo, reducing the inflammatory response in lipopolysaccharide (LPS) induced acute lung injury (ALI) . NBD-2 exhibits significant anti-inflammatory activity. NBD-2 can be used to study diseases related to NF-κB signaling pathway, including autoimmune diseases, cancer, etc[1].

• UNSPSC :

  12352209

• Target :

  NF-κB

• Type :

  Peptides

• Related Pathways :

  NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/nbd-2.html

• Smiles :

  O=C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CSC(C(F)=C1F)=C(F)C(F)=C1C2=C(F)C(F)=C3C(F)=C2F)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](CS3)C(N[C@@H](CC6=CNC7=CC=CC=C67)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N

• Molecular Formula :

  C73H86F8N14O17S2

• Molecular Weight :

  1647.66

• References & Citations :

  [1]Li S, et al. Development of a Decafluorobiphenyl Cyclized Peptide Targeting the NEMO–IKKα/β Interaction that Enhances Cell Penetration and Attenuates Lipopolysaccharide-Induced Acute Lung Injury[J]. Bioconjugate Chemistry, 2024.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported