NBD-2

• UNSPSC Description:

  NBD-2 is an inhibitor of the NEMO-IKKα/β interaction in the NF-κB signaling pathway. NBD-2 specifically inhibits the typical NF-κB signaling pathway in vitro and in vivo, reducing the inflammatory response in lipopolysaccharide (LPS) induced acute lung injury (ALI). NBD-2 exhibits significant anti-inflammatory activity. NBD-2 can be used to study diseases related to NF-κB signaling pathway, including autoimmune diseases, cancer, etc[1].

• Target Antigen:

  NF-κB

• Type:

  Peptides

• Related Pathways:

  NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/nbd-2.html

• Smiles:

  O=C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CSC(C(F)=C1F)=C(F)C(F)=C1C2=C(F)C(F)=C3C(F)=C2F)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](CS3)C(N[C@@H](CC6=CNC7=CC=CC=C67)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N

• Molecular Weight:

  1647.66

• References & Citations:

  [1]Li S, et al. Development of a Decafluorobiphenyl Cyclized Peptide Targeting the NEMO–IKKα/β Interaction that Enhances Cell Penetration and Attenuates Lipopolysaccharide-Induced Acute Lung Injury[J]. Bioconjugate Chemistry, 2024.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported