NBD-556

• Description:

  NBD-556, a CD4 mimetic, is a potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction. NBD-556 shows potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  HIV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/nbd-556.html

• Purity:

  99.57

• Solubility:

  DMSO : 33.33 mg/mL (ultrasonic)

• Smiles:

  O=C (C (NC1CC (C) (NC (C) (C1) C) C) =O) NC2=CC=C (C=C2) Cl

• Molecular Formula:

  C17H24ClN3O2

• Molecular Weight:

  337.84

• Precautions:

  H301

• References & Citations:

  [1]Schon A, et al. Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120. Biochemistry. 2006 Sep 12;45 (36) :10973-10980.|[2]Zhao Q, Ma L, Jiang S, Lu H, Liu S, He Y, Strick N, Neamati N, Debnath AK. Identification of N-phenyl-N'- (2,2,6,6-tetramethyl-piperidin-4-yl) -oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4. Virology. 2005 Sep 1;339 (2) :213-25.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HIV-1

• CAS Number:

  333353-44-9