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Pralidoxime (chloride)

CAT: 0804-HY-B1200-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1200-01Size:100 mg
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Description
Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE) . Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning[1][2].
CAS Number
51-15-0
Product Name Alternative
2-PAM chloride
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Pralidoxime-chloride.html
Concentration
10mM
Purity
99.83
Solubility
DMSO : 21.67 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
C[N+]1=CC=CC=C1/C=N/O.[Cl-]
Molecular Formula
C7H9ClN2O
Molecular Weight
172.61
Precautions
H302, H315, H319, H335
References & Citations
[1]Cadieux CL, et al. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chem Biol Interact. 2016;259 (Pt B) :133‐141.|[2]Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368 (9553) :2110‐2111.|[3]Houzé P, et al. High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice. Turk J Anaesthesiol Reanim. 2018;46 (2) :131‐138.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
AChE

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