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Pralidoxime

CAT: 0804-HY-B1738Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1738Size:1 mg
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Description
Pralidoxime is a potent reactivator of acetylcholinesterase (AChE) . Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning[1][2].
CAS Number
6735-59-7
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pralidoxime.html
Purity
90.0
Solubility
10 mM in DMSO
Smiles
C[N+]1=CC=CC=C1/C=N/O
Molecular Formula
C7H9N2O+
Molecular Weight
137.16
References & Citations
[1]Cadieux CL, et al. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chem Biol Interact. 2016;259 (Pt B) :133‐141.|[2]Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368 (9553) :2110‐2111.|[3]Houzé P, et al. High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice. Turk J Anaesthesiol Reanim. 2018;46 (2) :131‐138.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
AChE

Chemical Information

Pralidoxime

Pralidoxime is a pyridinium ion that is 1-methylpyridinium substituted by a (hydroxyimino)methyl group at position 2. It has a role as an antidote to sarin poisoning, a cholinergic drug, a cholinesterase reactivator and an antidote to organophosphate poisoning.

CAS Number6735-59-7
PubChem CID135398747
IUPAC Name(NE)-N-[(1-methylpyridin-1-ium-2-yl)methylidene]hydroxylamine
Molecular FormulaC7H9N2O+
Molecular Weight137.16
XLogP1
Topological Polar Surface Area36.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count10
Formal Charge1
Complexity125
SMILES
C[N+]1=CC=CC=C1/C=N/O
InChI
InChI=1S/C7H8N2O/c1-9-5-3-2-4-7(9)6-8-10/h2-6H,1H3/p+1
InChIKey
JBKPUQTUERUYQE-UHFFFAOYSA-O
Chemical Structure
2D Structure
2D structure of Pralidoxime
CAS: 6735-59-7
CID: 135398747
Formula: C7H9N2O+
MW: 137.16
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight137.16
XLogP31
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass137.071487915
Monoisotopic Mass137.071487915
Topological Polar Surface Area36.5 Ų
Heavy Atom Count10
Formal Charge1
Complexity125
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T73060-01Pralidoxime
592128Pralidoxime iodide
318556Pralidoxime Chloride
MBS5813002Pralidoxime mesylate

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