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FBX32 rabbit pAb

CAT: 0855-ES16504-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES16504-01Size:50 µL
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Background
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Description
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011],
Product Name Alternative
F-box only protein 32 (Atrogin-1) (Muscle atrophy F-box protein) (MAFbx)
UniProt
Q969P5
Swiss Prot
Q969P5
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human FBX32 AA range: 217-267
Target
FBX32
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Molecular Weight
38kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
38kD
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . Shuttles between cytoplasm and the nucleus.
Other Product Names
F-box only protein 32 (Atrogin-1) (Muscle atrophy F-box protein) (MAFbx)
Gene ID (Human)
114907

UniProtKB · Q969P5

F-box only protein 32

FBX32_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q969P5
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FBXO32
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A4KYM0
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Disease

Disease variant

Technical term

Proteomics identificationReference proteome

Biological process

Ubl conjugation pathway

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