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6β-Naltrexol

CAT: 0804-HY-108229-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108229-01Size:1 mg
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Description
6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit[1].
CAS Number
49625-89-0
Product Name Alternative
6β-Hydroxynaltrexone
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Metabolite; Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/6β-naltrexol.html
Purity
99.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@]12[C@@]34C5=C(C[C@@]2([H])N(CC6CC6)CC4)C=CC(O)=C5O[C@@]3([H])[C@H](O)CC1
Molecular Formula
C20H25NO4
Molecular Weight
343.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Cone EJ, et al. Biosynthesis, isolation, and identification of 6-beta-hydroxynaltrexone, a major human metabolite of naltrexone. J Pharm Sci. 1975 Apr;64 (4) :618-21.|[2]Yancey-Wrona J, et al. 6β-naltrexol, a peripherally selective opioid antagonist that inhibits morphine-induced slowing of gastrointestinal transit: an exploratory study. Pain Med. 2011 Dec;12 (12) :1727-37.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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