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BC-11 (hydrobromide)

CAT: 0804-HY-108447-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108447-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BC-11 hydrobromide is a selective TMPRSS2 inhibitor (TMPRSS2 is a key host cellular factor for viral entry and SARS-CoV-2 pathogenesis), and a selective urokinase (uPA) inhibitor (IC50=8.2 μM) . BC-11 hydrobromide is cytotoxic to triple-negative MDA-MB231 breast cancer cells. BC-11 hydrobromide is used in research on viral infections and cancer[1][2][3].
CAS Number
443776-49-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PAI-1; SARS-CoV; Ser/Thr Protease
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/bc-11-hydrobromide.html
Purity
99.0
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)
Smiles
NC(SCC1=CC=C(B(O)O)C=C1)=N.[H]Br
Molecular Formula
C8H12BBrN2O2S
Molecular Weight
290.98
Precautions
H302, H315, H319, H335
References & Citations
[1]Moumbock AFA, et al. BC-11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS-CoV-2 host cell entry. Arch Pharm (Weinheim) . 2023 Jan;356 (1) :e2200371.|[2]Semina E, et al. Urokinase and urokinase receptor participate in regulation of neuronal migration, axon growth and branching. Eur J Cell Biol. 2016 Sep;95 (9) :295-310.|[3]Longo A, et al. Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells. Molecules. 2015 May 28;20 (6) :9879-89.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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