REIIBP/NSD2 Recombinant Rabbit Monoclonal Antibody [PSH02-39]

REIIBP/NSD2 Recombinant Rabbit Monoclonal Antibody [PSH02-39]

• Description: NSD2 is a histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) . Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro . Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells. By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes. In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation. During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes. Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation. During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation. During B-cell development, required for the generation of the B1 lineage. During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response. Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation. By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA.
• Product Name Alternative: FLJ23286 antibody IL5 promoter REII region binding protein antibody KIAA1090 antibody MGC176638 antibody MMSET antibody MMSET type II antibody Multiple myeloma SET domain containing protein type III antibody Multiple myeloma SET domain protein antibody Multiple myeloma SET domain-containing protein antibody NSD 2 antibody NSD2 antibody NSD2_HUMAN antibody Nuclear receptor binding SET domain protein 2 antibody Nuclear SET domain-containing protein 2 antibody Probable histone-lysine N-methyltransferase NSD2 antibody Protein trithorax-5 antibody REIIBP antibody Trithorax/ash1 related protein 5 antibody TRX5 antibody TRX5 protein antibody WHS antibody Whsc1 antibody Wolf Hirschhorn syndrome candidate 1 antibody Wolf Hirschhorn syndrome candidate 1 protein antibody Wolf-Hirschhorn syndrome candidate 1 protein antibody
• Abbreviation: NSD2, KIAA1090, MMSET, TRX5, WHSC1
• CAS Number: 9000-83-3
• Swiss Prot: O96028 Hmuan, Q8BVE8 Mouse, D4A9J4 Rat
• Cellular Locus: Cytoplasm, nucleus, nucleolus
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within human NSD2 385-584 / 584 (O96028-4).
• Isotype: IgG
• Clone: PSH02-39
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: HeLa cell lysate, HEK-293 cell lysate, Neuro-2a cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, Rat testis tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 66 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes