Levonorgestrel

Levonorgestrel

• CAS Number: 797-63-7
• UNSPSC Description: Levonorgestrel is an orally active inhibitor of progesterone (HY-N0437). Levonorgestrel has anticancer activity and can induce Apoptosis. Levonorgestrel can be used as a contraceptive and in combination with other medications. Levonorgestrel can be used in the study of osteoporosis and uterine leiomyoma[1][2][3][4][5].
• Target Antigen: Apoptosis; Bcl-2 Family; Caspase; Survivin
• Type: Reference compound
• Related Pathways: Apoptosis
• Applications: Neuroscience-Neuromodulation
• Field of Research: Endocrinology; Cancer
• Assay Protocol: https://www.medchemexpress.com/Levonorgestrel.html
• Purity: 99.94
• Solubility: DMSO : 43.75 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : < 0.1 mg/mL
• Smiles: O=C1CC[C@]2([H])[C@@]3([H])CC[C@]4(CC)[C@@](C#C)(O)CC[C@@]4([H])[C@]3([H])CCC2=C1
• Molecular Weight: 312.45
• References & Citations: [1]Xu Qing, et al. Levonorgestrel inhibits proliferation and induces apoptosis in uterine leiomyoma cells. Contraception vol. 82,3 (2010): 301-8.|[2]Tellería C M, et al. Levonorgestrel inhibits luteinizing hormone-stimulated progesterone production in rat luteal cells. The Journal of steroid biochemistry and molecular biology vol. 50,3-4 (1994): 161-6. |[3]Liao Er-yuan, et al. Effects of different nylestriol/levonorgestrel dosages on bone metabolism in female Sprague-Dawley rats with retinoic acid-induced osteoporosis. Endocrine research vol. 29,1 (2003): 23-42. |[4]Chen Xiaoning, et al. Anti-fertility effect of levonorgestrel and/or quinestrol on striped field mouse (Apodemus agrarius): evidence from both laboratory and field experiments. Integrative zoology vol. 17,6 (2022): 1041-1052. |[5]Meng C-X, et al. Effects of oral and vaginal administration of levonorgestrel emergency contraception on markers of endometrial receptivity. Human reproduction (Oxford, England) vol. 25,4 (2010): 874-83.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched