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Levonorgestrel

CAT: 0804-HY-B0257-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0257-01Size:100 mg
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Description
Levonorgestrel is an orally active inhibitor of progesterone (HY-N0437) . Levonorgestrel has anticancer activity and can induce Apoptosis. Levonorgestrel can be used as a contraceptive and in combination with other medications. Levonorgestrel can be used in the study of osteoporosis and uterine leiomyoma[1][2][3][4][5].
CAS Number
[797-63-7]
Product Name Alternative
D-Norgestrel
UNSPSC
12352211
Hazard Statement
H351, H360
Target
Apoptosis; Bcl-2 Family; Caspase; Survivin
Type
Reference compound
Related Pathways
Apoptosis
Applications
Neuroscience-Neuromodulation
Field of Research
Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/Levonorgestrel.html
Concentration
10mM
Purity
99.98
Solubility
DMSO : 43.75 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL
Smiles
O=C1CC[C@]2([H])[C@@]3([H])CC[C@]4(CC)[C@@](C#C)(O)CC[C@@]4([H])[C@]3([H])CCC2=C1
Molecular Formula
C21H28O2
Molecular Weight
312.45
Precautions
H351, H360
References & Citations
[1]Xu Qing, et al. Levonorgestrel inhibits proliferation and induces apoptosis in uterine leiomyoma cells. Contraception vol. 82,3 (2010) : 301-8.|[2]Tellería C M, et al. Levonorgestrel inhibits luteinizing hormone-stimulated progesterone production in rat luteal cells. The Journal of steroid biochemistry and molecular biology vol. 50,3-4 (1994) : 161-6. |[3]Liao Er-yuan, et al. Effects of different nylestriol/levonorgestrel dosages on bone metabolism in female Sprague-Dawley rats with retinoic acid-induced osteoporosis. Endocrine research vol. 29,1 (2003) : 23-42. |[4]Chen Xiaoning, et al. Anti-fertility effect of levonorgestrel and/or quinestrol on striped field mouse (Apodemus agrarius) : evidence from both laboratory and field experiments. Integrative zoology vol. 17,6 (2022) : 1041-1052. |[5]Meng C-X, et al. Effects of oral and vaginal administration of levonorgestrel emergency contraception on markers of endometrial receptivity. Human reproduction (Oxford, England) vol. 25,4 (2010) : 874-83.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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