Levonorgestrel

• Description :

  Levonorgestrel is an orally active inhibitor of progesterone (HY-N0437) . Levonorgestrel has anticancer activity and can induce Apoptosis. Levonorgestrel can be used as a contraceptive and in combination with other medications. Levonorgestrel can be used in the study of osteoporosis and uterine leiomyoma[1][2][3][4][5].

• Product Name Alternative :

  D-Norgestrel

• UNSPSC :

  12352211

• Hazard Statement :

  H351, H360

• Target :

  Apoptosis; Bcl-2 Family; Caspase; Survivin

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Endocrinology; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Levonorgestrel.html

• Concentration :

  10mM

• Purity :

  99.98

• Solubility :

  DMSO : 43.75 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL

• Smiles :

  O=C1CC[C@]2([H])[C@@]3([H])CC[C@]4(CC)[C@@](C#C)(O)CC[C@@]4([H])[C@]3([H])CCC2=C1

• Molecular Formula :

  C21H28O2

• Molecular Weight :

  312.45

• Precautions :

  H351, H360

• References & Citations :

  [1]Xu Qing, et al. Levonorgestrel inhibits proliferation and induces apoptosis in uterine leiomyoma cells. Contraception vol. 82,3 (2010) : 301-8.|[2]Tellería C M, et al. Levonorgestrel inhibits luteinizing hormone-stimulated progesterone production in rat luteal cells. The Journal of steroid biochemistry and molecular biology vol. 50,3-4 (1994) : 161-6. |[3]Liao Er-yuan, et al. Effects of different nylestriol/levonorgestrel dosages on bone metabolism in female Sprague-Dawley rats with retinoic acid-induced osteoporosis. Endocrine research vol. 29,1 (2003) : 23-42. |[4]Chen Xiaoning, et al. Anti-fertility effect of levonorgestrel and/or quinestrol on striped field mouse (Apodemus agrarius) : evidence from both laboratory and field experiments. Integrative zoology vol. 17,6 (2022) : 1041-1052. |[5]Meng C-X, et al. Effects of oral and vaginal administration of levonorgestrel emergency contraception on markers of endometrial receptivity. Human reproduction (Oxford, England) vol. 25,4 (2010) : 874-83.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [797-63-7]