PDK-IN-3
CAT:
804-HY-157299-02
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PDK-IN-3
- UNSPSC Description: PDK-IN-3 (compound 1) is a potent pan inhibitor of PDK with IC50s of 109.3, 135.8, 458.7 nM and 8.67 μM against PDK 1-4, respectively. PDK-IN-3 also induces proliferation and apoptosis in A549 cells[1].
- Target Antigen: PDHK
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/pdk-in-3.html
- Solubility: DMSO : 66.67 mg/mL (ultrasonic;warming;adjust pH to 2 with 1 M HCL;heat to 60°C)
- Smiles: CC1=CC(C)=C(C=C1S(=O)(NCCO)=O)NS(=O)(C2=CC=C(C=C2)Cl)=O
- Molecular Weight: 418.92
- References & Citations: [1]Gan L, et al. Targeting the pyruvate dehydrogenase complex/pyruvate dehydrogenase kinase (PDC/PDK) axis to discover potent PDK inhibitors through structure-based virtual screening and pharmacological evaluation. Eur J Med Chem. 2023 Dec 3;264:116008.
- Shipping Conditions: Blue Ice
- Clinical Information: No Development Reported