PROTAC TBL1X degrader-1

• UNSPSC Description:

  PROTAC TBL1X degrader-1 (Compound TD11) is a PROTAC degrader for Transducin β-like protein 1 X-linked (TBL1X), and exhibits cytotoxicity in lymphoma cell Riva, Pfeiffer and Granta-519 with IC50 of 0.795, 0.397 and 0.522 μM, respectively. (Pink: ligand for target protein: TBL1X ligand 1 (HY-168191); Black: linker (HY-168193); Blue: ligand for E3 ligase: Thalidomide 4-fluoride (HY-41547))[1]

• Target Antigen:

  PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-tbl1x-degrader-1.html

• Smiles:

  O=S(C1=CC=C2C(/C(C(C=C(S(N3CC(C)CC(C)C3)(=O)=O)C=C4)=C4/C2=N\OCCCNC(CCCCNC5=C(C(N(C6C(NC(CC6)=O)=O)C7=O)=O)C7=CC=C5)=O)=N/O)=C1)(N8CC(C)CC(C)C8)=O

• Molecular Weight:

  1001.18

• References & Citations:

  [1]Yang R, et al., Design, Synthesis, and Biological Evaluation of Selective TBL1X Degraders. ACS Med Chem Lett. 2024 Oct 1;15(10):1699-1707.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported