Beta-NGF Recombinant Protein

• Background:

  β -NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β -NGF is a potent neurotrophic factor that signals through its receptor β -NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β -NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of Recombinant Human β -NGF is a non-covalently-linked homodimer of two 13.5 kDa, polypeptide monomers that each contain 120 amino acids and three disulfide bonds, which are required for biological activity.

• NCBI Gene ID:

  4803

• Swiss Prot:

  P01138

• Accession Number:

  NP_002497.2

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Cancer, Cell Cycle, Growth Factors, Neuroscience, Signal Transduction

• Purity:

  Greater than 98% by SDS-PAGE gel and HPLC analyses.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized Beta-NGF recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Beta-NGF stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Beta-NGF recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Nerve growth factor (beta polypeptide)

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  NGFB, HSAN5, Beta-NGF, NGFB, Beta-nerve growth factor

• Species:

  Human

• Protein ID:

  70995319

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3