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VSIG4 Recombinant Protein

CAT: 0223-96-780Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-96-780Size:0.1 mg
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Background
V-set and immunoglobulin domain-containing protein 4 (VSIG4) is also known as Protein Z39Ig, is a type I transmembrane glycoprotein. VSIG4 is a B7 family-related protein and an Ig superfamily member. VSIG4 contains two Ig-like (immunoglobulin-like) domains. VSIG4 is abundantly expressed in several fetal tissues. In adult tissues, the highest expression of VSIG4 is in lung and placenta. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. VSIG4 is a phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production.
CAS Number
9000-83-3
NCBI Gene ID
11326
Swiss Prot
Q9Y279
Accession Number
AAH10525
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
30 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
V-set and immunoglobulin domain containing 4
NCBI Organism
Homo sapiens
Background Reference 01
Vogt L., et al., 2006, J. Clin. Invest. 116:2817-2826.
Background Reference 02
Wiesmann C., et al., 2006, Nature 444:217-220.
Other Product Names
VSIG4, CRIg, Z39IG
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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