VEGF R3 / FLT4 Recombinant Protein

• Background:

  Vascular endothelial growth factor receptor 3 (VEGF R3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs) . VEGF R3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D. VEGF R3 is widely expressed in the early embryo but becomes restricted to lymphatic endothelia at later stages of development. It is likely that VEGF R3 may be important for lymph angiogenesis.

• NCBI Gene ID:

  14257

• Swiss Prot:

  P35917

• Accession Number:

  NP_032055.1

• Tag:

  Mouse IgG Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Immunology

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  50 mM Tris, 100 mM Glycine, pH7.5

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  111.5 kDa

• Applications Notes:

  This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 111.5 kDa. The protein migrates as 116-125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• NCBI Official Name:

  FMS-like tyrosine kinase 4

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Stuttfeld E., et al., 2009, IUBMB Life, 61 (9) : 915-922.

• Background Reference 02:

  Zygmunt T., et al., 2011, Dev Cell, 21 (2) : 301-314.

• Background Reference 03:

  Herzog, B., et al., 2011, Molecular Biology of the Cell, 22 (15) : 2766-2776.

• Other Product Names:

  Flt-4, FLT4, LMPH1A, PCLFLT41, VEGFR3, VEGFR-3, FLT-4, FLT-41, FLT41, PCL

• Tested Applications:

  ELISA, WB

• Species:

  Mouse

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3