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TREM2 Recombinant Protein

CAT: 0223-11-166Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-11-166Size:0.1 mg
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Background
Triggering receptor expressed on myeloid cells 2 (TREM2) is a cell surface receptor of the immunoglobulin superfamily. The TREM2 is found in various tissue macrophages, such as CNS microglia, bone osteoclasts, alveolar, peritoneal and intestinal macrophages. TREM2 is also present on cultured bone marrow-derived macrophages and monocyte-derived dendritic cells. Some research have identified a rare variant of TREM2 that is a risk factor for Alzheimer disease (AD), which is the most common form of late-onset dementia.The extracellular region of TREM2 contains a single immunoglobulin superfamily domain and binds polyanionic ligands, such as bacterial lipopolysaccharide (LPS) and phospholipids8. Upon ligand binding, TREM2 transmits intracellular signals through an adaptor, DAP12 (also known as TYRO protein tyrosine kinase-binding protein (TYROBP) ), which is associated with the transmembrane region of TREM2 and which recruits the protein tyrosine kinase SYK through its cytosolic immunoreceptor tyrosine-based activation motifs (ITAMs) . TREM2 is a pro-tumorigenic marker of tumor-infiltrating macrophages in mouse models and human tumors that can be targeted to curb tumor growth and improve the efficacy of checkpoint blockade therapy while remodeling the landscape of tumor-infiltrating macrophages.
CAS Number
9000-83-3
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Apoptosis, Cancer, Homeostasis, Immunology, Other
Purity
>90% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
18.7 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 18.7 kDa. The protein migrates as 25-45 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.
Background Reference 01
Martina Molgora, Ekaterina Esaulova et al. TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy.[J]. CELL, 2020.
Background Reference 02
Colonna M , Wang Y . TREM2 variants: new keys to decipher Alzheimer disease pathogenesis.[J]. Nature reviews Neuroence, 2016.
Background Reference 03
Karanfilian L , Tosto M G , Malki K . The Role of TREM2 in Alzheimer's Disease; Evidence from Transgenic Mouse Models[J]. Neurobiology of Aging, 2019.
Background Reference 04
Guerreiro R , Wojtas A , Bras J , et al. TREM2 variants in Alzheimer's disease.[J]. New England Journal of Medicine, 2013, 368 (2) .
Other Product Names
Triggering receptor expressed on myeloid cells 2/TREM2/TREM-2
Tested Applications
ELISA, WB
Species
Mouse
Physical Properties
Lyophilized

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