TREM2 Antibody

• Background :

  TREM2 is a membrane protein that forms a receptor signaling complex with TYROBP. The encoded protein may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) .

• NCBI Gene ID :

  54209

• Swiss Prot :

  Q9NZC2

• Accession Number :

  Q9NZC2

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This TREM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-50 amino acids from the N-terminal region of human TREM2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Immunology

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  25 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  TREM2

• NCBI Official Name :

  Triggering receptor expressed on myeloid cells 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Stefano, L., et al. J. Neurochem. 110 (1) :284-294 (2009)

• Background Reference 02 :

  Ford, J.W., et al. Curr. Opin. Immunol. 21 (1) :38-46 (2009)

• Other Product Names :

  Triggering receptor expressed on myeloid cells 2, TREM-2, Triggering receptor expressed on monocytes 2, TREM2

• Tested Applications :

  WB

• Protein ID :

  50401689

• Physical Properties :

  Liquid