LAP Recombinant Protein

• Background:

  Transforming growth factor beta 1 (TGFB1) is also known as TGF-beta1, CED, DPD1, TGFB. is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The TGFB1 protein helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (motility), and the self-destruction of cells (apoptosis) . The TGFB1 protein is found throughout the body and plays a role in development before birth, the formation of blood vessels, the regulation of muscle tissue and body fat development, wound healing, and immune system function. TGFB1 is particularly abundant in tissues that make up the skeleton, where it helps regulate bone growth, and in the intricate lattice that forms in the spaces between cells (the extracellular matrix) . Within cells, this protein is turned off (inactive) until it receives a chemical signal to become active. TGFB1 plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Most immune cells (or leukocytes) secrete TGFB1. TGFB1 has been shown to interact with TGF beta receptor 1, LTBP1, YWHAE, EIF3I and Decorin.

• NCBI Gene ID:

  7040

• Swiss Prot:

  P01137

• Accession Number:

  NP_000651 (C33S)

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Chemokines & Cytokines, Growth Factors

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  29.8 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Transforming growth factor beta-1 preproprotein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ghadami M, et al., 2000, Am. J. Hum. Genet. 66 : 143–7.

• Background Reference 02:

  Assoian R, et al., 1983, J Biol Chem , 258 (11) : 7155–60.

• Background Reference 03:

  Derynck R, et al., 1985, Nature 316 (6030) : 701–5.

• Background Reference 04:

  Letterio J, Roberts A, 1998, Annu Rev Immunol 16: 137–61.

• Other Product Names:

  LAP (TGF-beta 1), LAP (TGFB1), TGFB1, CED, DPD1, LAP, TGF-beta-1, TGFB

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3