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OPG Recombinant Protein

CAT: 0223-91-301Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-91-301Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL) . By binding RANKL, TNFRSF11B inhibits nuclear kappa B (NF-κB) which is a central and rapid acting transcription factor for immune-related genes, and a key regulator of inflammation, innate immunity, and cell survival and differentiation. TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2. TNFRSF11B can reduce the production of osteoclasts by inhibiting the differentiation of osteoclast precursors (osteoclasts are related to monocytes/macrophages and are derived from granulocyte/macrophage-forming colony units (CFU-GM) ) into osteoclasts and also regulates the resorption of osteoclasts in vitroand in vivo. TNFRSF11B binding to RANKL on osteoblast/stromal cells, blocks the RANKL-RANK ligand interaction between osteoblast/stromal cells and osteoclast precursors. This has the effect of inhibiting the differentiation of the osteoclast precursor into a mature osteoclast.
CAS Number
9000-83-3
NCBI Gene ID
4982
Swiss Prot
O00300
Accession Number
O00300
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Cell Cycle, Growth Factors, Immunology, Neuroscience, Obesity, Signal Transduction, Other
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
44.65 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Tumor necrosis factor receptor superfamily member 11b
NCBI Organism
Homo sapiens
Other Product Names
Tumor Necrosis Factor Receptor Superfamily Member 11B, Osteoclastogenesis Inhibitory Factor, Osteoprotegerin, TNFRSF11B, OCIF, OPG
Species
Human
Physical Properties
Lyophilized

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