TPA Recombinant Protein

Tissue-type plasminogen activator (PLAT) is a protein that secreted into extracellular space. PLAT contains five domains: EGF-like domain, fibronectin type-I domain, 2 kringle domains and peptidase S1 domain. It belongs to the peptidase S1 family. The main function of this protein is to convert plasminogen into biologically active plasmin. As a protease, PLAT plays a crucial role in regulating blood fibrinolysis, maintaining the homeostasis of extracellular matrix and in modulating the post-translational activation of growth factors. PLAT is found not only in the blood, where its primary function is as a thrombolytic enzyme, but also in the central nervous system (CNS) . It participates in a number of physiological and pathological events in the CNS, as well as the role of neuroserpin as the natural regulator of PLAT's activity in these processes. Increased or decreased activity of PLAT leads to hyperfibrinolysis or hypofibrinolysis, respectively. In addition, as a cytokine, PLAT plays a pivotal role in the pathogenesis of renal interstitial fibrosis through diverse mechanisms. Thus, as a fibrogenic cytokine, it promotes the progression of kidney diseases.

9000-83-3

5327

P00750

P00750

C-6 His tag

Recombinant Proteins

Human Cells

Cancer, Cell Cycle, Immunology, Obesity

Lyophilized from a 0.2 um filtered solution of 20mM MES,150mM NaCl,0.2mM GaCl2, pH5.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

Room Temp

61.65 kD

This recombinant protein can be used for biological assays. For research use only.

Plasminogen activator, tissue type

Homo sapiens

T-PA, TPA, t-plasminogen activator, Tissue plasminogen activator, PLAT

Human