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ZNRF3 Recombinant Protein

CAT: 0223-11-135Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-11-135Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) is a negative feedback regulator of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6 and acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway.
CAS Number
9000-83-3
NCBI Gene ID
84133
Swiss Prot
Q9ULT6
Accession Number
NP_001193927.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
19.7 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 19.7 kDa. The protein migrates as 22-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
Zincandringfinger3
NCBI Organism
Homo sapiens
Background Reference 01
Hao H.X. et al. 2012. Nature. 485 (7397) : 195–200.
Background Reference 02
Serra S.& Chetty R. 2018. Journal of Clinical Pathology 71 (1) : 1–6.
Background Reference 03
Hao H.X. et al. 2016. Cancers (Basel) 8 (6) .
Other Product Names
ZNRF3, Zinc/RING finger protein 3, RING-type E3 ubiquitin transferase ZNRF3, RING finger protein 203, KIAA1133, RNF203
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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