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CD86 Recombinant Protein

CAT: 0223-91-371Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-91-371Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. The protein interacts with MARCH8, human herpesvirus 8 MIR2 protein, adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.It contains 1 Ig-like C2-type (immunoglobulin-like) domainand 1 Ig-like V-type (immunoglobulin-like) domain.
CAS Number
9000-83-3
NCBI Gene ID
942
Swiss Prot
P42081
Accession Number
P42081
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Cancer, Cell Cycle, Immunology, Innate Immunity, Signal Transduction
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.2. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
26.69 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
CD86 molecule
NCBI Organism
Homo sapiens
Other Product Names
T-Lymphocyte Activation Antigen CD86, Activation B7-2 Antigen, B70, BU63, CTLA-4 Counter-Receptor B7.2, FUN-1, CD86, CD28LG2, B7-2
Species
Human
Protein ID
578833707
Physical Properties
Lyophilized

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