Pro-BDNF Recombinant Protein

CAT: 0223-91-063Size: 0.05 mgDry Ice: NoHazardous: No
CAT#:0223-91-063Size:0.05 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
CAS Number
9000-83-3
NCBI Gene ID
627
Swiss Prot
P23560
Accession Number
P23560
Tag
Tag Free
Type
Recombinant Proteins
Source
E. coli
Field of Research
Growth Factors, Neuroscience, Obesity, Signal Transduction, Stem Cell
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 250mM NaCl, pH 7.2. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
52 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Brain-derived neurotrophic factor
NCBI Organism
Homo sapiens
Other Product Names
Brain-Derived Neurotrophic Factor, BDNF, Abrineurin
Species
Human
Protein ID
578877726
Physical Properties
Lyophilized

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