Pro-BDNF Recombinant Protein

• Background:

  The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.

• NCBI Gene ID:

  627

• Swiss Prot:

  P23560

• Accession Number:

  P23560

• Tag:

  Tag Free

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Growth Factors, Neuroscience, Obesity, Signal Transduction, Stem Cell

• Buffer:

  Lyophilized from a 0.2 um filtered solution of 20mM PB, 250mM NaCl, pH 7.2. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  52 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Brain-derived neurotrophic factor

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Brain-Derived Neurotrophic Factor, BDNF, Abrineurin

• Species:

  Human

• Protein ID:

  578877726

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3