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POP1 Recombinant Protein

CAT: 0223-90-303Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0223-90-303Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL) -1beta and IL-18. Members of the Nod-like receptor family (NLRs), including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA) . Pyrin domain-containing protein 1 (POP1) interacts with the protein Asc (Pycard) and modulates the interaction of Asc to NLR proteins.
CAS Number
9000-83-3
NCBI Gene ID
260434
Swiss Prot
P09038
Accession Number
Q8WXC3
Tag
GST tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cell Cycle, Inflammasomes
Concentration
0.1mg/ml after reconstitution.
Purity
>95% (SDS-PAGE)
Buffer
Contains PBS. Reconstitute with 100 μ l sterile water.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 6 months after receipt when stored at -20˚ C.
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
PYD (pyrin domain) containing 1
NCBI Organism
Homo sapiens
Other Product Names
Pyrin Domain-containing Protein 1, PAAD-only Protein 1, Pyrin-only Protein 1, PYC1
Species
Human
Protein ID
74730989
Physical Properties
Lyophilized

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