SUMO1 Recombinant Protein

Small Ubiquitin-Related Modifier 1 (SUMO1) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation. SUMO1 functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. SUMO1 is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. SUMO1 is not active until the last four amino acids of the carboxy-terminus are cleaved off. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins and may also regulate a network of genes involved in palate development.

9000-83-3

7341

P63165

P63165

N-6 His tag

Recombinant Proteins

E. coli

Signal Transduction

Lyophilized from a 0.2 um filtered solution of 50mM TrisHCl, 100mM NaCl, 1mM DTT, pH 8.5 . It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

Room Temp

13.7 kD

This recombinant protein can be used for biological assays. For research use only.

Small ubiquitin-like modifier 1

Homo sapiens

Small Ubiquitin-Related Modifier 1, SUMO-1, GAP-Modifying Protein 1, GMP1, SMT3 Homolog 3, Sentrin, Ubiquitin-Homology Domain Protein PIC1, Ubiquitin-Like Protein SMT3C, Smt3C, Ubiquitin-Like Protein UBL1, SUMO1, SMT3H3, UBL1

Human