Products for Research Use Only
RegisterLogin

SLAMF7 Recombinant Protein

CAT: 0223-91-294Size: 0.05 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-91-294Size:0.05 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
SLAMF7 is a single-pass type I membrane protein and contains 1 Ig-like C2-type (immunoglobulin-like) domain. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM) -associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.
CAS Number
9000-83-3
NCBI Gene ID
57823
Swiss Prot
Q9NQ25
Accession Number
Q9NQ25
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Immunology
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
23.3 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
SLAM family member 7
NCBI Organism
Homo sapiens
Other Product Names
SLAM Family Member 7, CD2 Subset 1, CD2-Like Receptor-Activating Cytotoxic Cells, CRACC, Membrane Protein FOAP-12, Novel Ly9, Protein 19A, CD319, SLAMF7, CS1
Species
Human
Physical Properties
Lyophilized

Related Products

CatalogName
11-517SLAMF7 / CRACC / CD319 Recombinant Protein
11-463Rhesus macaque SLAMF7 / CRACC / CD319 Recombinant Protein
15-396SLAMF7 Antibody
19-857SLAMF7 Antibody
16-659SLAMF7 Antibody
62-007SLAMF7 Antibody
11-493SLAMF1 / SLAM / CD150 Recombinant Protein
10-307Elotuzumab (SLAMF7/CD319) - Research Grade Biosimilar
91-631SLAMF9 Recombinant Protein
91-354SLAMF6 Recombinant Protein

Alternative Products

CatalogName
OPCD07024-50UGSLAMF7 Recombinant Protein
MBS8249803-01Recombinant Human SLAMF7 Protein
TP723925SLAMF7 Human Recombinant Protein
RP028660SLAMF7 Recombinant Protein (Human)
TP727705Slamf7 Mouse Recombinant Protein
RP228854SLAMF7 Recombinant Protein (Rat)
RP172160SLAMF7 Recombinant Protein (Mouse)
GTR19124217-01Recombinant Mouse SLAMF7 Protein
PROTQ9NQ25-10ugHuman CRACC/SLAMF7 Recombinant Protein
TMPY-05387-01SLAMF7 Protein, Human, Recombinant (hFc)

Popular Products