SLAMF7 Antibody

• Background :

  SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain. Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway. It may play a role in lymphocyte adhesion. Isoform 3 does not mediate any activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro) . SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. The isoform 3 is expressed at much lower level than isoform 1. There are three named isoforms.

• NCBI Gene ID :

  57823

• Swiss Prot :

  Q9NQ25

• Accession Number :

  Q9NQ25

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This SLAMF7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-85 amino acids from the Central region of human SLAMF7.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Immunology

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  37 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  SLAMF7

• NCBI Official Name :

  SLAM family member 7

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Tovar, V., et al. Immunogenetics 54 (6) :394-402 (2002)

• Background Reference 02 :

  Murphy, J.J., et al. Biochem. J. 361 (PT 3), 431-436 (2002)

• Background Reference 03 :

  Bouchon, A., et al. J. Immunol. 167 (10) :5517-5521 (2001)

• Background Reference 04 :

  Boles, K.S., et al. Immunogenetics 52 (3-4), 302-307 (2001)

• Other Product Names :

  SLAM family member 7, CD2 subset 1, CD2-like receptor-activating cytotoxic cells, CRACC, Membrane protein FOAP-12, Novel Ly9, Protein 19A, CD319, SLAMF7, CS1

• Tested Applications :

  WB

• Protein ID :

  66774034

• Physical Properties :

  Liquid