SLAMF6 Recombinant Protein

CAT: 0223-91-354Size: 0.05 mgDry Ice: NoHazardous: No
CAT#:0223-91-354Size:0.05 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SLAM Family Member 6 (SLAMF6) is a 60 kD single-pass type I membrane protein that belongs to the SLAM subgroup of the CD2 family. Human SLAMF6/ NTB-A contains a 205 amino acid extracellular domain (ECD) with one Ig-like V-set and one Ig-like C2-set domain, a 21 amino acid transmembrane segment and an 84 amino acid cytoplasmic domain, with two immunoreceptor tyrosine-based switch motifs. SLAMF6 is a homodimer. SLAMF6 can interact with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. Phosphorylation-dependent NTB-A association with SAP is required for full production of IFN- gamma by NK cells and independent of EAT-2 binding. It Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. On B cells, NTB-A modulates immunoglobulin class switching and the balance between tolerance and autoimmunity.
CAS Number
9000-83-3
NCBI Gene ID
114836
Swiss Prot
Q96DU3
Accession Number
Q96DU3
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Immunology
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.2. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
23.98 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
SLAM family member 6
NCBI Organism
Homo sapiens
Other Product Names
SLAM Family Member 6, Activating NK Receptor, NK-T-B-Antigen, NTB-A, CD352, SLAMF6, KALI
Species
Human
Protein ID
530363504
Physical Properties
Lyophilized

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