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UPA Recombinant Protein

CAT: 0223-91-360Size: 0.05 mgDry Ice: YesHazardous: No
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CAT#:0223-91-360Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Recombinant Human Urokinase-Type Plasminogen Activator is a serine protease, which specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. Urokinase-Type Plasminogen Activator is a potent marker of invasion and metastasis in many human cancers associated with breast, colon, stomach, bladder, brain, ovary and endometrium. Human Urokinase-Type Plasminogen Activator is initially synthesized as 431 amino acid precursor with a N-terminal signal peptide residues. The single chain molecule is processed into a disulfide-linked two-chain molecule. There exists two forms A chain, the long A chain contains an EGF-like domain that is responsible for binding of the uPA receptor. The B chain corresponds to the catalytic domain.
CAS Number
9000-83-3
NCBI Gene ID
5328
Swiss Prot
P00749
Accession Number
P00749
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Cancer, Immunology, Neuroscience, Obesity
Buffer
Supplied as a 0.2 um filtered solution of 20mM HEPES, 150mM NaCl, 2mM CaCl, 10% Glycerol, pH 7.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Shipping Conditions
Dry Ice
Calculated Molecular Weight
47.41 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Plasminogen activator, urokinase
NCBI Organism
Homo sapiens
Other Product Names
Urokinase-Type Plasminogen Activator, U-Plasminogen Activator, uPA, PLAU, Urokinase
Species
Human
Physical Properties
Liquid

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