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PPP1R14A Recombinant Protein

CAT: 0223-91-142Size: 0.05 mgDry Ice: YesHazardous: No
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CAT#:0223-91-142Size:0.05 mg
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Background
Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime, PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. PPP1R14A is the inhibitor of PPP1CA. When phosphorylated, PPP1R14A has over 1000-fold higher inhibitory activity, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. In addition, inhibition of PPP1R14A also enhances contraction of smooth muscle in the absence of increment of intracellular Ca2+ concentration.
CAS Number
9000-83-3
NCBI Gene ID
94274
Swiss Prot
Q96A00
Accession Number
Q96A00
Tag
C-6 His tag
Type
Recombinant Proteins
Source
E. coli
Buffer
Supplied as a 0.2 um filtered solution of 20mM TrisHCl, 0.2mM EDTA, 1mM DTT, 10% Glycerol, pH 8.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Shipping Conditions
Dry Ice
Calculated Molecular Weight
17.76 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Protein phosphatase 1 regulatory inhibitor subunit 14A
NCBI Organism
Homo sapiens
Other Product Names
Protein Phosphatase 1 Regulatory Subunit 14A, 17 kDa PKC-Potentiated Inhibitory Protein of PP1, Protein Kinase C-Potentiated Inhibitor Protein of 17 kDa, CPI-17, PPP1R14A, CPI17, PPP1INL
Species
Human
Physical Properties
Liquid

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