Jagged 1 Recombinant Protein

• Background:

  Protein jagged-1 (JAG1) is also known as Jagged1, hJ1, JAGL1 and CD339, which is a single-pass type I membrane protein containing one DSL domain and 15 EGF-like domains. JAG1 is widely expressed in adult and fetal tissues, the expression of JAG1 is up-regulated in cervical squamous cell carcinoma and also expressed in bone marrow cell line HS-27a.JAG1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. JAG1 is involved in early and late stages of mammalian cardiovascular development. JAG1 inhibits myoblast differentiation by similarity and enhances fibroblast growth factor-induced angiogenesis (in vitro) .

• NCBI Gene ID:

  182

• Swiss Prot:

  P78504

• Accession Number:

  NP_000205

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cancer, Cell Cycle, Neuroscience, Stem Cell

• Purity:

  >92% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  112.3 kDa

• NCBI Official Name:

  Jagged 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Li L., et al., 1998, Immunity 8:43-55.

• Background Reference 02:

  Bash J., et al., 1999, EMBO J. 18:2803-2811.

• Background Reference 03:

  Zimrin A.B., et al., 1996, J. Biol. Chem. 271:32499-32502.

• Other Product Names:

  CD339, JAG1, Jagged1, hJ1, JAGL1

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3