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PDCD1 Recombinant Protein

CAT: 0223-91-596Size: 0.05 mgDry Ice: NoHazardous: No
91-5960.05 mg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Programmed cell death protein 1 (PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN- gamma by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
CAS Number
9000-83-3
NCBI Gene ID
5133
Swiss Prot
Q15116
Accession Number
Q15116
Tag
C-mFc tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Apoptosis, Cancer, Cell Cycle, Immunology
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB,150mM NaCl, pH7.2. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
42 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Programmed cell death 1
NCBI Organism
Homo sapiens
Other Product Names
Programmed cell death protein 1, hPD-1, PDCD1, CD279, PD-1
Species
Human
Physical Properties
Lyophilized

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